Sex Toys Blog, Sexual Health

011 Successful Treatment of Interstitial Cystitis/Bladder Pain Syndrome (IC/PBS) in Women with Provoked Vestibulodynia (PVD)

There is wide clinical overlap between provoked vestibulodynia (PVD) and IC/BPS as both conditions may include dyspareunia, chronic pelvic pain, and lower urinary tract symptoms. Unlike with IC/BPS evaluation, PVD patients are diagnosed by having confined vestibular pain and positive cotton swab (Q-tip) testing. Successful treatment of PVD has been anecdotally observed to resolve IC/BPS patient bladder symptoms. The goal of this study was to advance our knowledge concerning the association of successful treatment for PVD and subsequent bladder symptom improvement.

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Sex Toys Blog, Sexual Health

010 Simulation of Mid-Urethral Incontinence Sling Surgery Using Cadavers: Impact on Innervation and Glandular Tissue

The role of the female periurethral tissue in sexual function is not well understood. When mid-urethral sling (MUS) surgery is performed successfully to manage stress urinary incontinence sexual satisfaction can increase due to diminished urinary leakage. In contrast, this procedure has been reported to adversely impact orgasmic function and satisfaction, potentially because it transects periurethral tissue. This study histologically characterized innervation and glandular structures in periurethral tissue in female cadavers before and after a mid-urethral sling surgical simulation.

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Sex Toys Blog, Sexual Health

009 Histological Characterization of Periurethral Tissue: Potential Role in Sexual Function

The anatomy, structure, and function of the tissue adjacent to the anterior vaginal wall and surrounding the urethra has not been characterized sufficiently in the context of its role in female sexual function. This study histologically characterized the overall morphology as well as the location of the innervation and glandular in periurethral tissues collected from female cadavers.

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Sex Toys Blog, Sexual Health

008 Ivabradine (I(f) Funny Channel Current Blocker, CorlanorĀ®) Inhibits Human Corpus Cavernosum Contraction in Vitro via Interference with the Calcium and Potassium Transfer: A Potential Option for Erectile Dysfunction

High heart rate (HR) is an independent risk factor for erectile dysfunction (ED) The I(f) (Ifunny) or hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are involved in synaptic transmission and neuronal excitability under physiological conditions. The I(f) channel inhibitor ivabradine controls HR in the sinoatrial node and reduces myocardial oxygen demand without inducing hypotension. Only one study has explored HR reduction with ivabradine-improved ED parallel to decreased oxidative stress and penile fibrosis in atherosclerotic plaque load in ApoE-knockout mice.

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Sex Toys Blog, Sexual Health

007 The Effects of Local Delivery of Lipoic Acid and 4-Hydroxy-2,5,6-triaminopyrimidine Sulfate after Bilateral Nerve Crush Injury in the Rat Animal Model

To evaluate the effect of local delivery of lipoic acid (LA) and 4-hydroxy-2,5,6-triaminopyrimidine sulfate (HTAP) by polymeric microspheres in the bilateral cavernous nerve injury (BCNI) in the rat. LA is an antioxidant previously shown to improve neurogenic and endothelial cell dysfunction in the corpus cavernosa of diabetic rats through reduction of reactive oxygen species. HTAP is a novel, not yet extensively studied, multifunctional antioxidant with the potential to moderate peripheral nerve damage by similar mechanisms.

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Sex Toys Blog, Sexual Health

006 Topical Abdominal Application of Curcumin-containing Nanoparticles Protects Erectile Function and Correlates with Corporal Expression of Inflammatory Markers (HO-1 and Nf- kB) in a Rat Model of Type-2-diabetes

Although PDE5 inhibitors are the first line of therapy for men with erectile dysfunction (ED), patients with type 2 diabetes (T2D) are often refractory to this treatment. Chronic inflammation resulting from T2D contributes to the development of ED and curcumin, a natural anti-inflammatory compound, has recently been shown to have an effect on erectile function; however it is a molecule that exhibits poor oral bioavailability. To overcome this obstacle we designed a transdermal drug delivery system using nanoparticles to release curcumin (curc-NP) into the systemic blood circulation.

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Sex Toys Blog, Sexual Health

005 Improvement in Sexual Function Associated with Prostatic Artery Embolization (PAE): An Emerging Treatment Option for Men with Symptomatic BPH

There is a critical need for a minimally invasive treatment for symptomatic BPH, that does not adversely impact sexual function. Prostate artery embolization (PAE) is a new, FDA-approved treatment that significantly reduces symptom burden in patients with BPH, particularly in patients with larger prostate glands. We evaluated the impact of PAE on erectile and ejaculatory function in patients undergoing PAE at our center.

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Sex Toys Blog, Sexual Health

004 Convective Radiofrequency Thermal Therapy (RezumĀ®) Effectively Treats Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia Regardless of Obesity while Preserving Erectile and Ejaculatory Function

Obesity is a component of metabolic syndrome, which influences erectile dysfunction, lower urinary tract symptoms (LUTS), and response to benign prostatic hyperplasia (BPH) treatment. We assessed the effect of obesity on voiding and sexual function parameters in men treated with convective radiofrequency thermal therapy, Rezum (REZ), for LUTS/BPH and compared results between obese (BMI > 30) and non-obese subjects.

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